An American Werewolf in London (1981)

The movie of choice to get over 2046. Maybe its me, but i'm getting interpretations in this movie too :-)

An American Werewolf in London is a comedy/horror film released in 1981, written and directed by John Landis. The movie won the 1981 Saturn Award for Best Horror Film. Although there are several straightforward horror elements to the plot, it is also knowingly funny and ironic, an example of a tongue-in-cheek humour.